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Question of the month
Question of the Month

What is the natural history of untreated symptomatic osteonecrosis of the femoral head in SLE?

Email your answer on or before 15 Febuary, 2015 to: iraenewsletter@hotmail.com
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Best reply for the 'Question of the month-December'

HOW COMMON IS STATIN-ASSOCIATED MYOPATHY?

Answer:

Statin-associated muscle adverse events are not uncommon. Myalgia and myopathy occur with a frequency of 2–11%.1 However, severe myonecrosis and clinical rhabdomyolysis are much rarer (0.5% and <0.1%,  respectively).2–5 Patients can experience statin-induced myalgias without an elevation in serum creatine kinase (CK) concentration.

References
  1. Parker BA, Capizzi JA, Grimaldi AS, et al. Effect of statins on skeletal muscle function. Circulation 2013;127:96.
  2. Tobert JA. Efficacy and long-term adverse effect pattern of lovastatin. Am J Cardiol. 1988;62:28J.
  3. Dujovne CA, Chremos AN, Pool JL, et al. Expanded clinical evaluation of lovastatin (EXCEL) study results: IV. Additional perspectives on the tolerability of lovastatin. Am J Med. 1991;91:25S.
  4. Boccuzzi SJ, Bocanegra TS, Walker JF, et al. Long-term safety and efficacy profile of simvastatin. Am J Cardiol. 1991;68:1127.
  5. Pedersen TR, Berg K, Cook TJ, et al. Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study. Arch Intern Med. 1996;156:2085.